Each member of the epidermal growth factor receptor (EGFR) family plays a key role in normal development, homeostasis and a variety of pathophysiological conditions, most notably in cancer.According to the prevailing dogma, these four receptor tyrosine kinases (RTKs; EGFR, ERBB2, ERBB3 and ERBB4) function exclusively through the formation of homodi
This paper examines the intertextuality between two novels, Toenggoel by Eer Asura and Ronggeng Dukuh Paruk (RDP) by Ahmad Tohari.The intertextual relations can be said to be strengthening.Toenggoel clarifies the idea in RDP, in that a person who tries evening-dresses to reject a tradition is destined to possess a tragic fate: eliminated and isolat
Using the notion of tame regular d-path of the topological n-cube, we introduce the multiple-rings tame regular realization of a precubical set as a multipointed d-space.Its execution paths correspond to the nonconstant tame regular d-paths in the geometric realization of the precubicalset.The associated Moore flow gives rise to a functor from prec
Case summary A 3-year-old neutered male indoor British Shorthair cat was referred for a 2-week history of Tea Towel intermittent right forelimb lameness.Radiographic examination showed a diaphyseal monostotic, expansile, fusiform, lytic lesion in the right ulna.CT further defined the lesion and also demonstrated ipsilateral pulmonary consolidation.
In mammalian cells, DNA double-strand breaks (DSBs) are primarily repaired by nonhomologous end joining (NHEJ).The current model suggests that the Ku 70/80 heterodimer binds to DSB ends and recruits DNA-PKcs to form the active DNA-dependent protein kinase, DNA-PK.Subsequently, XRCC4, DNA ligase IV, XLF and most likely, other Clutch Spring unidentif